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Lookup NU author(s): Dr Amanda Thomson,
Professor Catharien Hilkens
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© Copyright © 2021 Thomson and Hilkens.Effective treatment of osteoarthritis (OA) remains a huge clinical challenge despite major research efforts. Different tissues and cell-types within the joint contribute to disease pathogenesis, and there is great heterogeneity between patients in terms of clinical features, genetic characteristics and responses to treatment. Inflammation and the most abundant immune cell type within the joint, macrophages, have now been recognised as possible players in disease development and progression. Here we discuss recent findings on the involvement of synovial inflammation and particularly the role of synovial macrophages in OA pathogenesis. Understanding macrophage involvement may hold the key for improved OA treatments.
Author(s): Thomson A, Hilkens CMU
Publication type: Review
Publication status: Published
Journal: Frontiers in Immunology
Online publication date: 15/06/2021
Acceptance date: 30/04/2021
ISSN (electronic): 1664-3224
Publisher: Frontiers Media S.A.