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Estimating an EQ-5D-3L Value Set for Romania Using Time Trade-Off

Lookup NU author(s): Dr Elena OlariuORCiD, Raluca Caplescu, Dr Yemi Oluboyede, Professor Luke ValeORCiD



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


© 2021 by the authors. Licensee MDPI, Basel, Switzerland.Objective: To provide health-related quality of life (HRQoL) data to support health technology assessment (HTA) and reimbursement decisions in Romania, by developing a country-specific value set for the EQ-5D-3L questionnaire. Methods: We used the cTTO method to elicit health state values using a computer-assisted personal interviewing approach. Interviews were standardized following the most recent version of the EQ-VT protocol developed by the EuroQoL Foundation. Thirty EQ-5D-3L health states were randomly assigned to respondents in blocks of three. Econometric modeling was used to estimate values for all 243 states described by the EQ-5D-3L. Results: Data from 1556 non-institutionalized adults aged 18 years and older, selected from a national representative sample, were used to build the value set. All tested models were logically consistent; the final model chosen to generate the value set was an interval regression model. The predicted EQ-5D-3L values ranged from 0.969 to 0.399, and the relative importance of EQ-5D-3L dimensions was in the following order: mobility, pain/discomfort, self-care, anxiety/depression, and usual activities. Conclusions: These results can support reimbursement decisions and allow regional cross-country comparisons between health technologies. This study lays a stepping stone in the development of a health technology assessment process more driven by locally relevant data in Romania.

Publication metadata

Author(s): Paveliu MS, Olariu E, Caplescu R, Oluboyede Y, Niculescu-Aron I-G, Ernu S, Vale L

Publication type: Article

Publication status: Published

Journal: International Journal of Environmental Research and Public Health

Year: 2021

Volume: 18

Issue: 14

Print publication date: 02/07/2021

Online publication date: 11/07/2021

Acceptance date: 07/07/2021

Date deposited: 21/07/2021

ISSN (print): 1661-7827

ISSN (electronic): 1660-4601

Publisher: MDPI AG


DOI: 10.3390/ijerph18147415


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