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Lookup NU author(s): Dr Sandip NandhraORCiD, Dr Ghazaleh Mohammadi-Zaniani
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© 2021 European Society for Vascular SurgeryObjective: This study aimed to develop and internally validate risk prediction models for predicting groin wound surgical site infections (SSIs) following arterial intervention and to evaluate the utility of existing risk prediction models for this outcome. Methods: Data from the Groin wound Infection after Vascular Exposure (GIVE) multicentre cohort study were used. The GIVE study prospectively enrolled 1 039 consecutive patients undergoing an arterial procedure through 1 339 groin incisions. An overall SSI rate of 8.6% per groin incision, and a deep/organ space SSI rate of 3.8%, were reported. Eight independent predictors of all SSIs, and four independent predictors of deep/organ space SSIs were included in the development and internal validation of two risk prediction models. A systematic search of the literature was conducted to identify relevant risk prediction models for their evaluation. Results: The “GIVE SSI risk prediction model” (“GIVE SSI model”) and the “GIVE deep/organ space SSI risk prediction model” (“deep SSI model”) had adequate discrimination (C statistic 0.735 and 0.720, respectively). Three other groin incision SSI risk prediction models were identified; both GIVE risk prediction models significantly outperformed these other risk models in this cohort (C statistic 0.618 – 0.629; p < .050 for inferior discrimination in all cases). Conclusion: Two models were created and internally validated that performed acceptably in predicting “all” and “deep” groin SSIs, outperforming current existing risk prediction models in this cohort. Future studies should aim to externally validate the GIVE models.
Author(s): Gwilym BL, Ambler GK, Saratzis A, Bosanquet DC, Stather P, Singh A, Mancuso E, Arifi M, Altabal M, Elhadi A, Althini A, Ahmed H, Davies H, Rangaraju M, Juszczak M, Nicholls J, Platt N, Olivier J, Kirkham E, Cooper D, Roy I, Harrison G, Ackah J, Mittapalli D, Barry I, Richards T, Elbasty A, Moore H, Bajwa A, Duncan A, Batchelder A, Vanias T, Brown M, Yap T, Green L, Smith G, Hurst K, Rodriguez DU, Schofield E, Danbury H, Wallace T, Forsyth J, Stimpson A, Hopkins L, Mohiuddin K, Nandhra S, Mohammadi-Zaniani G, Tigkiropoulos K, Shalan A, Bashar K, Sam R, Forrest C, Debono S, Hussey K, Falconer R, Korambayil S, Brennan C, Wilson T, Jones A, Hardy T, Burton H, Cowan A, Contractor U, Townsend E, Grant O, Cronin M, Rocker M, Lowry D, Clothier A, Locker D, Forsythe R, McBride O, Eng C, Jamieson R, Altaf N, Picazo F, Sieunarine K, Benson RA, Crichton A, Dattani N, Akhtar T, Suttenwood H, Guest F, Wardle B, Dovell G, Chinai N, Bosanquet D, Hinchliffe R, Beckitt T, Wafi A, Thapar A, Moxey P, Lane T, Preece R, Naidoo K, Patterson B, Perrott C, Shalhoub J, Aherne T, Hassanin A, Boyle E, Egan B, Tierney S, Patel S, Birmpili P, Kandola S, Neequaye S, Elhadi M, Msherghi A, Khaled A, Meecham L, Fisher O, Mahmood A, Milgrom D, Burke K, Saleh F, Al-Samarneh T
Publication type: Article
Publication status: Published
Journal: European Journal of Vascular and Endovascular Surgery
Year: 2021
Volume: 62
Issue: 2
Pages: 258-266
Print publication date: 01/08/2021
Online publication date: 08/07/2021
Acceptance date: 08/05/2021
ISSN (print): 1078-5884
ISSN (electronic): 1532-2165
Publisher: W.B. Saunders Ltd
URL: https://doi.org/10.1016/j.ejvs.2021.05.009
DOI: 10.1016/j.ejvs.2021.05.009
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