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A biocompatibility study of injectable poly(caprolactone-trifumarate) for use as a bone substitute material

Lookup NU author(s): Dr Nisreen Al-NamnamORCiD

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This is the authors' accepted manuscript of an article that has been published in its final definitive form by Taylor & Francis, 2015.

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Abstract

The need for bone graft alternatives has led to the development of numerous bone graft substitutes. Here, the authors have synthesized a biodegradable poly(caprolactone-trifumarate) (PCLTF) polymer solution that could be injected into any bony defect. This polymer solution was synthesized using polycaprolactone-triol and fumaryl chloride (FCl). PCLTF is a multiple-branching, unsaturated and cross-linkable in situ material. The surface microstructure of PCLTF was investigated using a field emission scanning electron microscope. The incorporation of double bonds originating from FCl into the poly(caprolactone) backbone was confirmed in the Fourier transform infrared spectra. The in vitro cytotoxic effects of PCLTF, its leachable extracts and degradation products were evaluated in direct and indirect contact tests against human oral fibroblasts. Cell viability was evaluated using the microculture tetrazolium assay and cytotoxicity evaluations of PCLTF were tested in accordance with ISO 10993-5 standards. The results showed that there was evidence of reasonable cell growth, good cell viability and intact cell morphology after exposure to PCLTF, its extracts and degradation products. There was no evidence of critical cytotoxic effects.

Publication metadata

Author(s): Al-Namnam NM, Kim KH, Chai WL, Ha KO, Siar CH, Ngeow WC

Publication type: Article

Publication status: Published

Journal: Frontiers in Life Science

Year: 2015

Volume: 8

Issue: 3

Pages: 215-222

Print publication date: 02/07/2015

Online publication date: 16/07/2015

Acceptance date: 11/05/2015

Date deposited: 27/07/2021

ISSN (print): 2689-5293

ISSN (electronic): 2689-5307

Publisher: Taylor & Francis

URL: https://doi.org/10.1080/21553769.2015.1051240

DOI: 10.1080/21553769.2015.1051240

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