Browse by author
Lookup NU author(s): Dr Nisreen Al-NamnamORCiD
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Objectives: To assess and compare the quantity and the quality of the new bone generated when using chitosan-based gel scaffold and osteoprotegerin-chitosan gel scaffold. Methods: A total of 18 critical-sized defects on New Zealand white rabbit craniums were created. In 12 defects, either chitosan gel or osteoprotegerin-chitosan gel was implanted the last six defects were kept unfilled as a control. Bone formation was examined at 6 and 12 weeks. Bone’s specimens were scanned using High-resolution peripheral quantitative computed tomography. Histological and histomorphometric analyses were carried out to compare the volume and area of regenerated bone. Results: The results of the HR-pQCT showed that bone volume and densities in the osteoprotegerin-chitosan gel group were significantly higher than the chitosan gel and control groups whereas, the bone volume density in the chitosan gel group was significantly higher than the control group in both intervals time (p 0.01, p 000). No significant difference in bone volume between the chitosan gel and control groups (p 0.506, p 0.640) was observed. However, similar findings were shown in the histomorphometric analysis, with the highest new bone formation was observed in the OPG-chitosan gel group followed by the chitosan group. The mean percentage of new bone was greater at 12 weeks compared to 6 weeks in all groups. Conclusions: Chitosan-based gel demonstrated a significant bone quantity and quality compared to unfilled surgical defects. Consistently, osteoprotegerin enhanced the chitosan gel in bone regeneration.
Author(s): Jayash SN, Hashim NM, Misran M, Ibrahim N, AL-Namnam NM, Baharuddin NA
Publication type: Article
Publication status: Published
Journal: Frontiers in Materials
Year: 2021
Volume: 8
Online publication date: 30/03/2021
Acceptance date: 05/02/2021
Date deposited: 25/07/2021
ISSN (electronic): 2296-8016
Publisher: Frontiers Research Foundation
URL: https://doi.org/10.3389/fmats.2021.640950
DOI: 10.3389/fmats.2021.640950
Altmetrics provided by Altmetric
