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Lookup NU author(s): Dr Laura Lane, Professor Judith RankinORCiD, Professor Timothy Cheetham
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2020 The Authors. Clinical Endocrinology published by John Wiley & Sons Ltd. Objective: A suboptimal quality of life (QoL) has been reported in patients with Graves’ disease treated in adult life, but long-term QoL in those treated in childhood and adolescence is unclear. We wanted to understand how Graves’ disease and its management impact on the physical, psychological and social well-being of young people and their longer-term QoL. Design, patients and measurements: Two questionnaires were used to assess QoL and patient experience of Graves’ disease; PedsQL™ Generic Core Scales and a Graves’ disease questionnaire devised for this project. The anonymized questionnaires were sent to young people (<30 years) diagnosed with Graves’ disease in childhood and adolescence and managed at a tertiary paediatric endocrine unit in the North of England. Respondent QoL scores were compared with a healthy UK cohort. Results: Questionnaires were sent to 51 young people, and 26 responded (51%). Graves’ patients reported a lower total QoL score compared with the healthy cohort (p =.003). This was particularly apparent in the psychosocial domain (p =.0016). No patient regretted having definitive treatment (surgery/radioiodine), and all said they would recommend it to others. Half of those who had received definitive treatment still did not feel recovered. There was no difference in the long-term QoL in those who did/did not receive definitive treatment (p =.40). Conclusions: This study highlights short- and long-term impacts on the QoL and general well-being of young people with Graves’ disease. There were no regrets regarding the choice of definitive treatment. This information will help inform the counselling of patients and their families.
Author(s): Lane LC, Rankin J, Cheetham T
Publication type: Article
Publication status: Published
Journal: Clinical Endocrinology
Year: 2021
Volume: 94
Issue: 2
Pages: 330-340
Print publication date: 01/02/2021
Online publication date: 31/10/2020
Acceptance date: 27/10/2020
Date deposited: 26/07/2021
ISSN (print): 0300-0664
ISSN (electronic): 1365-2265
Publisher: John Wiley & Sons Ltd
URL: https://doi.org/10.1111/cen.14359
DOI: 10.1111/cen.14359
PubMed id: 33128233
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