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Lookup NU author(s): Dr Calum Hamilton, Julia SchumacherORCiD, Professor Fiona MatthewsORCiD, Professor John-Paul TaylorORCiD, Dr Louise Allan, Nicola Barnett, Dr Ruth Cromarty, Dr Paul Donaghy, Dr Rory Durcan, Dr Michael FirbankORCiD, Dr Sarah Lawley, Professor John O'Brien, Professor Alan ThomasORCiD
This is the authors' accepted manuscript of an article that has been published in its final definitive form by Cambridge University Press, 2021.
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Electroencephalographic (EEG) abnormalities are greater in mild cognitive impairment (MCI) with Lewy bodies (MCI-LB) than in MCI due to Alzheimer’s disease (MCI-AD) and may anticipate onset of dementia. We aimed to assess whether quantitative EEG (qEEG) slowing would predict a higher annual hazard of dementia in MCI across these aetiologies. MCI patients (n=92) and healthy comparators (n=31) provided qEEG recording and underwent longitudinal clinical and cognitive follow-up. Associations between qEEG slowing, measured by increased theta/alpha ratio, and clinical progression from MCI to dementia were estimated with a multi-state transition model to account for death as a competing risk, while controlling for age, cognitive function, and aetiology classified by an expert consensus panel. Over a mean follow up of 1.5 years (SD = 0.5) fourteen cases of incident dementia and five deaths were observed. Increased theta/alpha ratio on qEEG was associated with increased annual hazard of dementia (Hazard Ratio = 1.84, 95% CI: 1.01–3.35). This extends previous findings that MCI-LB features early functional changes, showing that qEEG slowing may anticipate onset of dementia in prospectively-identified MCI.
Author(s): Hamilton C, Schumacher J, Matthews FE, Taylor JP, Allan L, Barnett N, Cromarty R, Donaghy P, Durcan R, Firbank M, Lawley S, O'Brien JT, Roberts G, Thomas A
Publication type: Article
Publication status: Published
Journal: International Psychogeriatrics
Year: 2021
Volume: 33
Issue: Special Issue 12
Pages: 1321-1325
Print publication date: 01/12/2021
Online publication date: 23/09/2021
Acceptance date: 29/07/2021
Date deposited: 16/08/2021
ISSN (print): 1041-6102
ISSN (electronic): 1741-203X
Publisher: Cambridge University Press
URL: https://doi.org/10.1017/S1041610221001083
DOI: 10.1017/S1041610221001083
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