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Slowing on quantitative EEG is associated with transition to dementia in mild cognitive impairment

Lookup NU author(s): Dr Calum Hamilton, Julia SchumacherORCiD, Professor Fiona MatthewsORCiD, Professor John-Paul TaylorORCiD, Dr Louise Allan, Nicola Barnett, Dr Ruth Cromarty, Dr Paul Donaghy, Dr Rory Durcan, Dr Michael FirbankORCiD, Dr Sarah Lawley, Professor John O'Brien, Professor Alan ThomasORCiD

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This is the authors' accepted manuscript of an article that has been published in its final definitive form by Cambridge University Press, 2021.

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Abstract

Electroencephalographic (EEG) abnormalities are greater in mild cognitive impairment (MCI) with Lewy bodies (MCI-LB) than in MCI due to Alzheimer’s disease (MCI-AD) and may anticipate onset of dementia. We aimed to assess whether quantitative EEG (qEEG) slowing would predict a higher annual hazard of dementia in MCI across these aetiologies. MCI patients (n=92) and healthy comparators (n=31) provided qEEG recording and underwent longitudinal clinical and cognitive follow-up. Associations between qEEG slowing, measured by increased theta/alpha ratio, and clinical progression from MCI to dementia were estimated with a multi-state transition model to account for death as a competing risk, while controlling for age, cognitive function, and aetiology classified by an expert consensus panel. Over a mean follow up of 1.5 years (SD = 0.5) fourteen cases of incident dementia and five deaths were observed. Increased theta/alpha ratio on qEEG was associated with increased annual hazard of dementia (Hazard Ratio = 1.84, 95% CI: 1.01–3.35). This extends previous findings that MCI-LB features early functional changes, showing that qEEG slowing may anticipate onset of dementia in prospectively-identified MCI.


Publication metadata

Author(s): Hamilton C, Schumacher J, Matthews FE, Taylor JP, Allan L, Barnett N, Cromarty R, Donaghy P, Durcan R, Firbank M, Lawley S, O'Brien JT, Roberts G, Thomas A

Publication type: Article

Publication status: Published

Journal: International Psychogeriatrics

Year: 2021

Volume: 33

Issue: Special Issue 12

Pages: 1321-1325

Print publication date: 01/12/2021

Online publication date: 23/09/2021

Acceptance date: 29/07/2021

Date deposited: 16/08/2021

ISSN (print): 1041-6102

ISSN (electronic): 1741-203X

Publisher: Cambridge University Press

URL: https://doi.org/10.1017/S1041610221001083

DOI: 10.1017/S1041610221001083


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