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History, versatility and future prospects of oscillatory carbonylation reactions of alkynes

Lookup NU author(s): Dr Katarina Novakovic



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


© The Royal Society of Chemistry 2021. The paper looks back at three decades of oscillatory carbonylation reactions, summarises core findings and shares perspectives, with particular emphasis on applications. Oscillatory carbonylation reactions of alkynes display remarkable versatility in terms of substrates, catalysts and solvents. Furthermore, in addition to oscillations in pH and redox potential, these organic chemical oscillators can yield oscillations in turbidity and release heat from the reaction in a pulsatile manner. Recent research developments shift attention from small molecule substrates (e.g.phenylacetylene) and small molecule catalysts (e.g.palladium(ii) iodide), to oscillatory carbonylation reactions using polymeric substrates (e.g.PEGylated alkynes) and polymeric catalysts (e.g.imine-functionalized chitosan-palladium) and use of these polymeric building blocks to develop oscillatory (pulsatile) materials fit for pulsatile drug release and other applications.

Publication metadata

Author(s): Novakovic K, Bruk L, Temkin O

Publication type: Review

Publication status: Published

Journal: RSC Advances

Year: 2021

Volume: 11

Issue: 39

Pages: 24336-24344

Online publication date: 12/07/2021

Acceptance date: 21/06/2021

ISSN (electronic): 2046-2069

Publisher: Royal Society of Chemistry


DOI: 10.1039/d1ra03810a