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Curcumin and biochemical parameters in metabolic-associated fatty liver disease (MAFLD)—A review

Lookup NU author(s): Emerita Professor Julia Newton



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


© 2021 by the authors. Licensee MDPI, Basel, Switzerland. Metabolic-associated fatty liver disease (MAFLD), formerly non-alcoholic fatty liver disease (NAFLD), is characterized by excessive fat accumulation in hepatocytes. It is the most common chronic liver disease worldwide and is a significant public health problem. In the absence of pharmacological therapy, other treatments such as diet, physical activity, or supplementation are sought. Non-pharmacological therapies may include curcumin supplementation, which has been shown to have many health-promoting properties, including antioxidant, anti-inflammatory, and anti-cancer effects. For this reason, we reviewed available databases to analyze publications describing the effect of curcumin supplementation on biochemical parameters in MAFLD. Nine studies (eight RCTs and one CT) based solely on supplementation of patients with curcumin were included in this re-view. The results from the individual trials were varied and did not allow clear conclusions. Alt-hough they suggest that curcumin shows some potential in the treatment of MAFLD, further research is needed.

Publication metadata

Author(s): Rozanski G, Kujawski S, Newton JL, Zalewski P, Slomko J

Publication type: Review

Publication status: Published

Journal: Nutrients

Year: 2021

Volume: 13

Issue: 8

Online publication date: 30/07/2021

Acceptance date: 28/07/2021

ISSN (electronic): 2072-6643

Publisher: MDPI AG


DOI: 10.3390/nu13082654