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Fabrication and characterisation of two types of bone composites made of chitosan-genipin hydrogel and Bioglass 45S5

Lookup NU author(s): Đurđa Vukajlović, Dr Oana Bretcanu, Dr Katarina Novakovic



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Synthetic inorganic-organic composites are of interest for bone tissue engineering as analternative to natural grafts, since they resemble the structure of natural bone and degrade over time,enabling new bone to grow. In this study, properties of two types of composite materials: Type 1)genipin cross-linked chitosan hydrogels with the addition of Bioglass 45S5 (BG) powder and Type 2)BG scaffolds coated with the genipin cross-linked chitosan hydrogel, have been investigated usingscanning electron microscopy (SEM), FTIR spectroscopy, fluorescence intensity (FI) measurement andcompression tests. The composites were immersed in the simulated body fluid (SBF) for up to 2 weeksand their structure and mechanical properties were examined. Results showed that addition of BGpowder to the chitosan hydrogels improved the compressive stress of the hydrogels both before andafter immersion in SBF. However, the low values of the mechanical properties do not make themsuitable for bone tissue applications. In the case of BG scaffolds coated with the chitosan-genipinhydrogel, the coating improved the mechanical properties of the scaffolds after immersion in SBF.Hydrogel coated BG scaffolds showed potential for low load-bearing applications, as an alternative tocommonly used collagen and hydroxyapatite.

Publication metadata

Author(s): Vukajlovic Dj, Bretcanu O, Novakovic K

Publication type: Article

Publication status: Published

Journal: Open Ceramics

Year: 2021

Volume: 8

Print publication date: 01/12/2021

Online publication date: 26/08/2021

Acceptance date: 23/08/2021

Date deposited: 28/08/2021

ISSN (electronic): 2666-5395

Publisher: Elsevier


DOI: 10.1016/j.oceram.2021.100174


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