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Lookup NU author(s): Đurđa Vukajlović, Dr Oana Bretcanu, Professor Katarina Novakovic
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Synthetic inorganic-organic composites are of interest for bone tissue engineering as analternative to natural grafts, since they resemble the structure of natural bone and degrade over time,enabling new bone to grow. In this study, properties of two types of composite materials: Type 1)genipin cross-linked chitosan hydrogels with the addition of Bioglass 45S5 (BG) powder and Type 2)BG scaffolds coated with the genipin cross-linked chitosan hydrogel, have been investigated usingscanning electron microscopy (SEM), FTIR spectroscopy, fluorescence intensity (FI) measurement andcompression tests. The composites were immersed in the simulated body fluid (SBF) for up to 2 weeksand their structure and mechanical properties were examined. Results showed that addition of BGpowder to the chitosan hydrogels improved the compressive stress of the hydrogels both before andafter immersion in SBF. However, the low values of the mechanical properties do not make themsuitable for bone tissue applications. In the case of BG scaffolds coated with the chitosan-genipinhydrogel, the coating improved the mechanical properties of the scaffolds after immersion in SBF.Hydrogel coated BG scaffolds showed potential for low load-bearing applications, as an alternative tocommonly used collagen and hydroxyapatite.
Author(s): Vukajlovic Dj, Bretcanu O, Novakovic K
Publication type: Article
Publication status: Published
Journal: Open Ceramics
Year: 2021
Volume: 8
Print publication date: 01/12/2021
Online publication date: 26/08/2021
Acceptance date: 23/08/2021
Date deposited: 28/08/2021
ISSN (electronic): 2666-5395
Publisher: Elsevier
URL: https://doi.org/10.1016/j.oceram.2021.100174
DOI: 10.1016/j.oceram.2021.100174
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