Toggle Main Menu Toggle Search

Open Access padlockePrints

Baseline clinical characteristics of predicted structural and pain progressors in the IMI-APPROACH knee OA cohort

Lookup NU author(s): Professor Jaume Bacardit, Dr Paweł Widera



This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).


© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.To describe the relations between baseline clinical characteristics of the Applied Public-Private Research enabling OsteoArthritis Clinical Headway (IMI-APPROACH) participants and their predicted probabilities for knee osteoarthritis (OA) structural (S) progression and/or pain (P) progression. Baseline clinical characteristics of the IMI-APPROACH participants were used for this study. Radiographs were evaluated according to Kellgren and Lawrence (K&L grade) and Knee Image Digital Analysis. Knee Injury and Osteoarthritis Outcome Score (KOOS) and Numeric Rating Scale (NRS) were used to evaluate pain. Predicted progression scores for each individual were determined using machine learning models. Pearson correlation coefficients were used to evaluate correlations between scores for predicted progression and baseline characteristics. T-tests and χ2tests were used to evaluate differences between participants with high versus low progression scores. Participants with high S progressions score were found to have statistically significantly less structural damage compared with participants with low S progression scores (minimum Joint Space Width, minJSW 3.56 mm vs 1.63 mm; p<0.001, K&L grade; p=0.028). Participants with high P progression scores had statistically significantly more pain compared with participants with low P progression scores (KOOS pain 51.71 vs 82.11; p<0.001, NRS pain 6.7 vs 2.4; p<0.001). The baseline minJSW of the IMI-APPROACH participants contradicts the idea that the (predicted) course of knee OA follows a pattern of inertia, where patients who have progressed previously are more likely to display further progression. In contrast, for pain progressors the pattern of inertia seems valid, since participants with high P score already have more pain at baseline compared with participants with a low P score.

Publication metadata

Author(s): van Helvoort EM, Ladel C, Mastbergen S, Kloppenburg M, Blanco FJ, Haugen IK, Berenbaum F, Bacardit J, Widera P, Welsing PMJ, Lafeber F

Publication type: Article

Publication status: Published

Journal: RMD Open

Year: 2021

Volume: 7

Issue: 3

Print publication date: 01/08/2021

Online publication date: 23/08/2021

Acceptance date: 14/08/2021

Date deposited: 09/09/2021

ISSN (electronic): 2056-5933

Publisher: BMJ Publishing Group


DOI: 10.1136/rmdopen-2021-001759


Altmetrics provided by Altmetric