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Exploring the roles of neuropeptides in trigeminal neuropathic pain: A systematic review and narrative synthesis of animal studies

Lookup NU author(s): Nontawat Chuinsiri, David Edwards, Dr Seva TelezhkinORCiD, Dr Christopher NileORCiD, Professor Justin DurhamORCiD


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© 2021 Elsevier Ltd. Objective: This systematic review aims to explore the changes in expression of neuropeptides and/or their receptors following experimental trigeminal neuropathic pain in animals. Design: MEDLINE, Embase, and Scopus were searched for publications up to 31st March 2021. Study selection and data extraction were completed by two independent reviewers based on the eligibility criteria. The quality of articles was judged based on the Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE) risk-of-bias tool. Results: A total of 19 studies satisfied the eligibility criteria and were included for narrative synthesis. Methods of trigeminal neuropathic pain induction were nerve ligation, nerve compression/crush, nerve transection and dental pulp injury. Animal behaviours used for pain verification were evoked responses to mechanical and thermal stimuli. Non-evoked behaviours, including vertical exploration, grooming and food consumption, were also employed in some studies. Calcitonin gene-related peptide (CGRP) and substance P were the most frequently reported neuropeptides. Overall, unclear to high risk of bias was identified in the included studies. Conclusions: Limited evidence has suggested the pro-nociceptive role of CGRP in trigeminal neuropathic pain. In order to further translational pain research, animal models of trigeminal neuropathic pain and pain validation methods need to be optimised. Complete reporting of future studies based on available guidelines to improve confidence in research is encouraged.

Publication metadata

Author(s): Chuinsiri N, Edwards D, Telezhkin V, Nile CJ, Van der Cruyssen F, Durham J

Publication type: Review

Publication status: Published

Journal: Archives of Oral Biology

Year: 2021

Volume: 130

Print publication date: 01/10/2021

Online publication date: 24/08/2021

Acceptance date: 22/08/2021

ISSN (print): 0003-9969

ISSN (electronic): 1879-1506

Publisher: Elsevier Ltd


DOI: 10.1016/j.archoralbio.2021.105247