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Systematic review of the incidence and risk factors for chyle leak after pancreatic surgery. Surgery

Lookup NU author(s): Professor Sanjay PandanaboyanaORCiD

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Abstract

Background: The incidence of and risk factors for chyle leak, as defined by the 2017 International Study Group on Pancreatic Surgery, remain unknown.Methods: MEDLINE, EMBASE, and Scopus were systematically searched for studies of patients undergoing pancreatectomy that reported chyle leak according to the 2017 International Study Group on Pancreatic Surgery definition. The primary outcomes were the incidence of overall and clinically relevant chyle leak. A random-effects pairwise meta-analysis was used to calculate the incidence of chyle leak.Results: Thirty-five studies including 7,083 patients were included in the meta-analysis. The weighted incidence of overall chyle leak was 6.8% (95% confidence interval 5.6-8.2), and clinically relevant chyle leak was 5.5% (95% confidence interval 3.8-7.7). Pancreaticoduodenectomy, total pancreatectomy, and distal pancreatectomy were associated with a CL incidence of 7.3%, 4.3%, and 5.8%, respectively. Fourteen individual risk factors for chyle leak were identified from included studies. Younger age, low prognostic nutritional index, para-aortic node manipulation, lymphatic involvement, and post-pancreatectomy pancreatitis were significantly associated with chyle leak, all from individual studies.Conclusion: The incidence of overall chyle leak and clinically relevant chyle leak after pancreatic surgery, as defined by the 2017 International Study Group on Pancreatic Surgery, is 6.8% and 5.5%, respectively. Several risk factors for chyle leak were identified in the present review; however, larger high-quality studies are needed to more accurately define these risks.

Publication metadata

Author(s): Varghese C, Wells CI, Lee S, Pathak S, Siriwardena AK, Pandanaboyana S

Publication type: Article

Publication status: Published

Journal: Surgery

Year: 2022

Volume: 171

Issue: 2

Pages: 490-497

Print publication date: 01/02/2022

Online publication date: 17/08/2021

Acceptance date: 15/07/2021

ISSN (electronic): 0039-6060

Publisher: Elsevier

URL: https://doi.org/10.1016/j.surg.2021.07.021

DOI: 10.1016/j.surg.2021.07.021

PubMed id: 34417025

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