Toggle Main Menu Toggle Search

Open Access padlockePrints

Olfactory Impairment in Mild Cognitive Impairment with Lewy Bodies and Alzheimer’s Disease

Lookup NU author(s): Professor Alan ThomasORCiD, Dr Calum Hamilton, Sally Barker, Rory Durcan, Dr Sarah Lawley, Nicola Barnett, Dr Michael FirbankORCiD, Dr Gemma RobertsORCiD, Dr Louise Allan, Professor John O'Brien, Professor John-Paul TaylorORCiD, Dr Paul Donaghy

Downloads


Licence

This is the authors' accepted manuscript of an article that has been published in its final definitive form by Cambridge University Press, 2022.

For re-use rights please refer to the publisher's terms and conditions.


Abstract

Objectives Impaired olfaction may be a biomarker for early Lewy body disease but its value in Mild Cognitive Impairment with Lewy bodies (MCI-LB) is unknown. We compared olfaction in MCI-LB with MCI due to Alzheimer’s disease (MCI-AD) and healthy older adults. We hypothesised that olfactory function would be worse in probable MCI-LB than in both MCI-AD and healthy comparison subjects (HC). Design Cross-sectional study assessing olfaction using Sniffin’ Sticks 16 (SS-16) in MCI-LB, MCI-AD and HC with longitudinal follow-up. Differences were adjusted for age and receiver operating characteristic curves were used for discriminating MCI-LB from MCI-AD andHC. Setting Participants were recruited from Memory Services in the North East of England Participants 38 probable MCI-LB, 33 MCI-AD, 19 possible MCI-LB and 32HC. Measurements Olfaction was assessed using SS-16 and a questionnaire. Results Participants with probable MCI-LB had worse olfaction than both MCI-AD (Age-adjusted mean difference (B)=2.05,95% CI:0.62-3.49, p=.005) and HC (B=3.96, 95% CI:2.51–5.40, p<.001). The previously-identified cut-off score for the SS-16 of ≤ 10 had 84% sensitivity for probable MCI-LB (95% CI: 69-94%) but 30% specificity vs MCI-AD. ROC analysis found a lower cut-off of ≤ 7 was better (63% sensitivity for MCI-LB, with 73% specificity vs MCI-AD and 97% vsHC). Asking about olfactory impairments was not useful in identifying them. Conclusions MCI-LB had worse olfaction than MCI-AD and normal ageing. A lower cut-off score of ≤ 7 is required when using SS-16 in such patients. Olfactory testing may have value in identifying early LB disease in memory services.


Publication metadata

Author(s): Thomas AJ, Hamilton CA, Barker S, Durcan R, Lawley S, Barnett N, Firbank M, Roberts G, Allan L, O'Brien J, Taylor JP, Donaghy PC

Publication type: Article

Publication status: Published

Journal: International Psychogeriatrics

Year: 2022

Volume: 34

Issue: Special Issue 6

Pages: 585-592

Online publication date: 20/09/2021

Acceptance date: 07/09/2021

Date deposited: 20/09/2021

ISSN (print): 1041-6102

ISSN (electronic): 1741-203X

Publisher: Cambridge University Press

URL: https://doi.org/10.1017/S1041610221001265

DOI: 10.1017/S1041610221001265


Altmetrics

Altmetrics provided by Altmetric


Share