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Lookup NU author(s): Dr Diana PapiniORCiD, Dr Mark Levasseur, Professor Jonathan HigginsORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Kinetochores assemble on chromosomes in mitosis to allow microtubules to attach and bring about accurate chromosome segregation. The kinases Cyclin B-Cdk1 and Aurora B are crucial for the formation of stable kinetochores. However, the activity of these two kinases appears to decline dramatically at centromeres during anaphase onset, precisely when microtubule attachments are required to move chromosomes towards opposite poles of the dividing cell. We find that, although Aurora B leaves centromeres at anaphase, a gradient of Aurora B activity centred on the central spindle is still able to phosphorylate kinetochore substrates such as Dsn1 to modulate kinetochore stability in anaphase and to regulate kinetochore disassembly as cells enter telophase. We provide a model to explain how Aurora B co-operates with Cyclin B-Cdk1 to maintain kinetochore function in anaphase.
Author(s): Papini D, Levasseur MD, Higgins JMG
Publication type: Article
Publication status: Published
Journal: Cell Reports
Year: 2021
Volume: 37
Issue: 6
Print publication date: 09/11/2021
Online publication date: 09/11/2021
Acceptance date: 17/09/2021
Date deposited: 12/11/2021
ISSN (electronic): 2211-1247
Publisher: Cell Press
URL: https://doi.org/10.1016/j.celrep.2021.109818
DOI: 10.1016/j.celrep.2021.109818
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