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Classification of positive margins after resection of soft-tissue sarcoma of the limb predicts the risk of local recurrence

Lookup NU author(s): Craig Gerrand


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We considered whether a positive margin occurring after resection of a soft-tissue sarcoma of a limb would affect the incidence of local recurrence. Patients with low-grade liposarcomas were expected to be a low-risk group as were those who had positive margins planned before surgery to preserve critical structures. Two groups, however, were expected to be at a higher risk, namely, patients who had undergone unplanned excision elsewhere with a positive margin on re-excision and those with unplanned positive margins occurring during primary resection. Of 566 patients in a prospective database, 87 with positive margins after limb-sparing surgery and adjuvant radiotherapy were grouped according to the clinical scenario by an observer blinded to the outcome. The rate of local recurrence differed significantly between the two low- (4.2% and 3.6%) and the two high-risk groups (31.6% and 37.5%). This classification therefore provides useful information about the incidence of local recurrence after positive-margin resection.

Publication metadata

Author(s): Gerrand CH, Wunder JS, Kandel RA, OSullivan B, Catton CN, Bell RS, Griffin AM, Davis AM

Publication type: Article

Publication status: Published

Journal: Journal of Bone and Joint Surgery - British Volume

Year: 2001

Volume: 83

Issue: 8

Pages: 1149-55

Print publication date: 01/11/2001

ISSN (print): 0301-620X

ISSN (electronic): 0968-7300


DOI: 10.1302/0301-620X.83B8.12028


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