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Lookup NU author(s): Dr Matthew GermanORCiD
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By means of an ESR spin-trapping method, we have shown that Ab (amyloid b), a-synuclein and various toxic forms of the prion protein all appear to generate H2O2 in vitro. A fundamental molecular mechanism underlying the pathogenesis of cell death in several different neurodegenerative diseases could be the direct production of H2O2 during the early stages of protein aggregation.
Author(s): Tabner BJ, Turnbull S, Fullwood N, German MJ, Allsop D
Publication type: Article
Publication status: Published
Journal: Biochemical Society Transactions
ISSN (print): 0300-5127
ISSN (electronic): 1470-8752
Publisher: Portland Press Ltd.
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