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The production of hydrogen peroxide during early-stage protein aggregation: a common pathological mechanism in different neurodegenerative diseases?

Lookup NU author(s): Dr Matthew GermanORCiD


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By means of an ESR spin-trapping method, we have shown that Ab (amyloid b), a-synuclein and various toxic forms of the prion protein all appear to generate H2O2 in vitro. A fundamental molecular mechanism underlying the pathogenesis of cell death in several different neurodegenerative diseases could be the direct production of H2O2 during the early stages of protein aggregation.

Publication metadata

Author(s): Tabner BJ, Turnbull S, Fullwood N, German MJ, Allsop D

Publication type: Article

Publication status: Published

Journal: Biochemical Society Transactions

Year: 2005

Volume: 33

Issue: 4

Pages: 548-550

ISSN (print): 0300-5127

ISSN (electronic): 1470-8752

Publisher: Portland Press Ltd.


DOI: 10.1042/BST0330548


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