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When nonsense makes sense and vice versa: Noncanonical decoding events at stop codons in eukaryotes

Lookup NU author(s): Dr Victoriya Doronina, Dr Jeremy Brown


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Abstract —Regulation of protein synthesis at the level of translation termination is a relatively underexplored, but rapidly expanding field. Recent advances in elucidating the mechanism of translation termination are helping to understand noncanonical events associated with translation termination. These “recoding” events include read-through of stop codons, insertion of unusual amino acids such as selenocysteine, and production of several polypeptides from one open reading frame. This review summarizes data on termination-dependent recoding events and proposes that there are two types of stop codon-associated sequences optimized to perform different functions: termination of translation per se or alternative elongation events

Publication metadata

Author(s): Doronina VA, Brown JD

Publication type: Review

Publication status: Published

Journal: Molecular Biology

Year: 2006

Volume: 40

Issue: 4

Pages: 654-663

ISSN (print): 0026-8933

ISSN (electronic): 1608-3245


DOI: 10.1134/S0026893306040182

PubMed id: 16913232