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Does prepregnancy weight change have an effect on subsequent pregnancy health outcomes? A systematic review and meta-analysis

Lookup NU author(s): Dr Malcolm Moffat, Dr Louise HayesORCiD, Dr Nicola HeslehurstORCiD


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© 2021 World Obesity Federation. International guidelines recommend women with an overweight or obese body mass index (BMI) aim to reduce their body weight prior to conception to minimize the risk of adverse perinatal outcomes. Recent systematic reviews have demonstrated that interpregnancy weight gain increases women's risk of developing adverse pregnancy outcomes in their subsequent pregnancy. Interpregnancy weight change studies exclude nulliparous women. This systematic review and meta-analysis was conducted following MOOSE guidelines and summarizes the evidence of the impact of preconception and interpregnancy weight change on perinatal outcomes for women regardless of parity. Sixty one studies met the inclusion criteria for this review and reported 34 different outcomes. We identified a significantly increased risk of gestational diabetes (OR 1.88, 95% CI 1.66, 2.14, I2 = 87.8%), hypertensive disorders (OR 1.46 95% CI 1.12, 1.91, I2 = 94.9%), preeclampsia (OR 1.92 95% CI 1.55, 2.37, I2 = 93.6%), and large-for-gestational-age (OR 1.36, 95% CI 1.25, 1.49, I2 = 92.2%) with preconception and interpregnancy weight gain. Interpregnancy weight loss only was significantly associated with increased risk for small-for-gestational-age (OR 1.29 95% CI 1.11, 1.50, I2 = 89.9%) and preterm birth (OR 1.06 95% CI 1.00, 1.13, I2 = 22.4%). Our findings illustrate the need for effective preconception and interpregnancy weight management support to improve pregnancy outcomes in subsequent pregnancies.

Publication metadata

Author(s): Nagpal TS, Souza SCS, Moffat M, Hayes L, Nuyts T, Liu RH, Bogaerts A, Dervis S, Piccinini-Vallis H, Adamo KB, Heslehurst N

Publication type: Article

Publication status: Published

Journal: Obesity Reviews

Year: 2022

Volume: 23

Issue: 1

Print publication date: 01/01/2022

Online publication date: 25/10/2021

Acceptance date: 05/07/2021

ISSN (print): 1467-7881

ISSN (electronic): 1467-789X

Publisher: John Wiley and Sons Inc.


DOI: 10.1111/obr.13324


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