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Cytoplasmic DNA: sources, sensing, and role in aging and disease

Lookup NU author(s): Hanna Salmonowicz


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© 2021Endogenous cytoplasmic DNA (cytoDNA) species are emerging as key mediators of inflammation in diverse physiological and pathological contexts. Although the role of endogenous cytoDNA in innate immune activation is well established, the cytoDNA species themselves are often poorly characterized and difficult to distinguish, and their mechanisms of formation, scope of function and contribution to disease are incompletely understood. Here, we summarize current knowledge in this rapidly progressing field with emphases on similarities and differences between distinct cytoDNAs, their underlying molecular mechanisms of formation and function, interactions between cytoDNA pathways, and therapeutic opportunities in the treatment of age-associated diseases.

Publication metadata

Author(s): Miller KN, Victorelli SG, Salmonowicz H, Dasgupta N, Liu T, Passos JF, Adams PD

Publication type: Review

Publication status: Published

Journal: Cell

Year: 2021

Volume: 184

Issue: 22

Pages: 5506-5526

Print publication date: 28/10/2021

Online publication date: 28/10/2021

Acceptance date: 02/04/2018

ISSN (print): 0092-8674

ISSN (electronic): 1097-4172

Publisher: Elsevier B.V.


DOI: 10.1016/j.cell.2021.09.034