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Lookup NU author(s): Victoria Renwick,
Dr Christopher Stewart
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2021 The Authors. Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica. Aim: Metabolomics is the study of small molecules that represent the functional end points of cellular reactions that can impact health. Necrotising enterocolitis (NEC) and late onset sepsis (LOS) are the main cause of death in preterm infants surviving the initial days of life. Methods: This review will explore and summarise the current literature exploring metabolomics in preterm infants. Results: There are a relatively limited number of studies investigating metabolomics in preterm infants with NEC and/or LOS and matched controls. Nonetheless, it is evident across longitudinally age-related metabolomic studies that there are significant changes in metabolite profiles post-partum and over the first year of life. Existing studies have reported associations between the metabolite profiles of serum, urine and stool in health and disease in preterm infants. Although some studies have found selected metabolites are associated with disease, the specific metabolites vary from study to study, and larger studies are required. Excitingly, recent work has also begun to untangle how microbially produced metabolites can impact immunoregulation of the infant. Conclusion: Metabolic exploration is an emerging research area with huge potential for developing novel biomarkers and better understanding disease processes in preterm infants.
Author(s): Renwick VL, Stewart CJ
Publication type: Review
Publication status: Published
Journal: Acta Paediatrica
Print publication date: 01/01/2022
Online publication date: 09/10/2021
Acceptance date: 08/10/2021
ISSN (print): 0803-5253
ISSN (electronic): 1651-2227
Publisher: John Wiley and Sons Inc