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Biomarkers for the Assessment of Exposure to Fluoride in Adults

Lookup NU author(s): Dr Oladipo IdowuORCiD, Dr Ralph Duckworth, Professor Ruth Valentine, Dr Vida Zohoori


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To monitor deficient or excessive intakes of biologically available fluoride (F), various biological samples have been tested for use as biomarkers of human exposure to F. Most such studies have concerned children and often have only involved measurement of F in 1 or 2 types of sample. The present study investigated the relationships of F concentrations in biomarkers of F exposure; including plasma, saliva, hair, finger- and toenails, and daily urinary F excretion (UFE) with the total daily F intake (TDFI) of adults. TDFI was assessed in 60 healthy adults, aged ≥20 years; 31 lived in a low-F water area (LFA, 0.04 mg F/L) and 29 in a high-F water area (HFA, 3.05 mg F/L) of Nigeria. All volunteers provided at least 1 biomarker sample from the above list and completed a questionnaire to evaluate F intake from the diet and toothpaste ingestion. TDFI, UFE and F concentrations of biomarkers were statistically significantly higher in the HFA than in the LFA. There were strong statistically significant positive correlations between TDFI and UFE (ρ = 0.730, p < 0.001); plasma F (ρ = 0.729, p < 0.001); fasting whole saliva F (ρ = 0.653, p < 0.001) and hair F (ρ = 0.603, p < 0.001). The statistically significant positive correlations between TDFI and fingernail F (ρ = 0.502, p < 0.001) and between TDFI and toenail F (ρ = 0.556, p < 0.001) were moderate. In conclusion, this study has indicated the usefulness of 24-h UFE as well as F concentration in plasma, fasting whole saliva and hair as biomarkers of contemporary or sub-chronic F exposure in groups of adults. However, they do not appear to have the necessary sensitivity to predict F exposure in individuals.© 2021 S. Karger AG, Basel

Publication metadata

Author(s): Idowu OS, Duckworth RM, Valentine RA, Zohoori FV

Publication type: Article

Publication status: Published

Journal: Caries Research

Year: 2021

Volume: 55

Issue: 4

Pages: 292-300

Print publication date: 01/08/2021

Online publication date: 01/06/2021

Acceptance date: 21/03/2021

ISSN (print): 0008-6568

ISSN (electronic): 1421-976X

Publisher: Karger Publishers


DOI: 10.1159/000516091


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