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Radical C-H Trifluoromethoxylation of (Hetero)arenes with Bis(trifluoromethyl)peroxide

Lookup NU author(s): Dr Matt HopkinsonORCiD



This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).


Bis(trifluoromethyl)peroxide (BTMP) is introduced as a new reagent for the C−H trifluoromethoxylation of arenes and heteroarenes. Readily accessed from inexpensive bulk chemicals, BTMP serves as a practical source of OCF3 radicals upon activation through either visible light photoredox or TEMPO catalysis. Both methods deliver valuable fluorine-containing building blocks in a single step from (hetero)aromatic feedstocks.

Publication metadata

Author(s): Dix S, Golz P, Schmid JR, Riedel S, Hopkinson MN

Publication type: Article

Publication status: Published

Journal: Chemistry - A European Journal

Year: 2021

Volume: 27

Issue: 45

Pages: 11554-11558

Print publication date: 11/08/2021

Online publication date: 02/07/2021

Acceptance date: 07/06/2021

Date deposited: 16/11/2021

ISSN (print): 0947-6539

ISSN (electronic): 1521-3765

Publisher: Wiley


DOI: 10.1002/chem.202101621


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