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Lookup NU author(s): James Hunter,
Dr Harriet Stanway-Gordon,
Professor Mike Waring
This is the authors' accepted manuscript of an article that has been published in its final definitive form by American Chemical Society, 2021.
For re-use rights please refer to the publisher's terms and conditions.
DNA-encoded libraries (DELs) offer great promise for the discovery of new ligands for proteins. Many current reactions used for DEL synthesis do not proceed efficiently over a wide range of substrates. Combining a diverse array of multicomponent reactions with micellar-promoted Suzuki-Miyaura cross coupling provides a strategy for synthesizing highly diverse DELs with exceptionally high fidelity. These results demonstrate that the micellar Suzuki-Miyaura reaction has exceptional functional group tolerance and broad applicability.
Author(s): Hunter JH, Potowski M, Stanway-Gordon HA, Madin A, Pairaudeau G, Brunschweiger A, Waring MJ
Publication type: Article
Publication status: Published
Journal: Journal of Organic Chemistry
Print publication date: 17/12/2021
Online publication date: 24/11/2021
Acceptance date: 11/11/2021
Date deposited: 16/11/2021
ISSN (print): 0022-3263
ISSN (electronic): 1520-6904
Publisher: American Chemical Society
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