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Functional group tolerance of a micellar on-DNA Suzuki-Miyaura cross-coupling reaction for DNA-encoded library design

Lookup NU author(s): James Hunter, Harriet Stanway-Gordon, Professor Mike Waring

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This is the authors' accepted manuscript of an article that has been published in its final definitive form by American Chemical Society, 2021.

For re-use rights please refer to the publisher's terms and conditions.


Abstract

DNA-encoded libraries (DELs) offer great promise for the discovery of new ligands for proteins. Many current reactions used for DEL synthesis do not proceed efficiently over a wide range of substrates. Combining a diverse array of multicomponent reactions with micellar-promoted Suzuki-Miyaura cross coupling provides a strategy for synthesizing highly diverse DELs with exceptionally high fidelity. These results demonstrate that the micellar Suzuki-Miyaura reaction has exceptional functional group tolerance and broad applicability.


Publication metadata

Author(s): Hunter JH, Potowski M, Stanway-Gordon HA, Madin A, Pairaudeau G, Brunschweiger A, Waring MJ

Publication type: Article

Publication status: Published

Journal: Journal of Organic Chemistry

Year: 2021

Volume: 86

Issue: 24

Pages: 17930-17935

Print publication date: 17/12/2021

Online publication date: 24/11/2021

Acceptance date: 11/11/2021

Date deposited: 16/11/2021

ISSN (print): 0022-3263

ISSN (electronic): 1520-6904

Publisher: American Chemical Society

URL: https://doi.org/10.1021/acs.joc.1c02259

DOI: 10.1021/acs.joc.1c02259


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Funding

Funder referenceFunder name
Cancer Research UK (C2115/A21421
EP/R51309X/1

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