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Using Rh(III)-catalyzed C-H activation as a tool for the selective functionalization of ketone-containing molecules

Lookup NU author(s): Dr Matt HopkinsonORCiD

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Abstract

Due to the strong potential of C-H activation in many areas of organic chemistry, the use of a pre-existing carbonyl group for the installation of a directing group to enable selective and predictable α-alkenylation with activated olefins as coupling partners is described. This Heck-type reaction would then lead either to β,γ-unsaturated ketones or to variously substituted 1,4-butadienes depending on the conditions used for the cleavage of the directing group. © 2014 American Chemical Society.

Publication metadata

Author(s): Boultadakis-Arapinis M, Hopkinson MN, Glorius F

Publication type: Article

Publication status: Published

Journal: Organic Letters

Year: 2014

Volume: 16

Issue: 6

Pages: 1630-1633

Print publication date: 21/03/2014

Online publication date: 03/03/2014

Acceptance date: 23/01/2014

ISSN (print): 1523-7060

ISSN (electronic): 1523-7052

Publisher: American Chemical Society

URL: https://doi.org/10.1021/ol500258q

DOI: 10.1021/ol500258q

PubMed id: 24588566

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