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Human alpha-aminoadipic semialdehyde synthase (AASS); A Target Enabling Package.

Lookup NU author(s): Dr Sabrina MackinnonORCiD, Dr Paul Brennan


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This work provides the early tools to develop substrate reduction inhibitors for a genetic childhood seizure disorder, with the hypothesis to target the enzyme (AASS) upstream of the defective gene (ALDH7A1) in the human lysine metabolic pathway. This TEP package includes recombinant human AASS purification protocols, structures of the AASS second domain in different states, in vitro assays to detect ligand binding (differential scanning fluorimetry) and enzyme activity (NADH formation) of human AASS, as well as initial chemical matters.

Publication metadata

Author(s): Kopec J, Pena I, Rembeza E, McLaughlin M, Fedorov O, Strain-Damerell C, Goubin S, MacKinnon S, Burgess-Brown N, Brennan P, MacKenzie A, Arruda P, Yue WW

Publication type: Online Publication

Publication status: Published

Series Title:

Year: 2017

Access Year: 2022

Acceptance date: 02/06/2017

Publisher: Zenodo

Place Published: Geneva

Access Date: 8 April


DOI: 10.5281/zenodo.1219674.