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Associations between body mass index across adult life and hip shapes at age 60 to 64: Evidence from the 1946 British birth cohort

Lookup NU author(s): Professor Rachel CooperORCiD



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


© 2017 The Author(s)Objective To examine the associations of body mass index (BMI) across adulthood with hip shapes at age 60–64 years. Methods Up to 1633 men and women from the MRC National Survey of Health and Development with repeat measures of BMI across adulthood and posterior-anterior dual-energy X-ray absorptiometry bone mineral density images of the proximal femur recorded at age 60–64 were included in analyses. Statistical shape modelling was applied to quantify independent variations in hip mode (HM), of which the first 6 were examined in relation to: i) BMI at each age of assessment; ii) BMI gain during different phases of adulthood; iii) age first overweight. Results Higher BMI at all ages (i.e. 15 to 60–64) and greater gains in BMI were associated with higher HM2 scores in both sexes (with positive HM2 values representing a shorter femoral neck and a wider and flatter femoral head). Similarly, younger age first overweight was associated with higher HM2 scores but only in men once current BMI was accounted for. In men, higher BMI at all ages was also associated with lower HM4 scores (with negative HM4 values representing a flatter femoral head, a wider neck and smaller neck shaft angle) but no associations with BMI gain or prolonged exposure to high BMI were found. Less consistent evidence of associations was found between BMI and the other four HMs. Conclusion These results suggest that BMI across adulthood may be associated with specific variations in hip shapes in early old age.

Publication metadata

Author(s): Muthuri SG, Saunders FR, Hardy RJ, Pavlova AV, Martin KR, Gregory JS, Barr RJ, Adams JE, Kuh D, Aspden RM, Cooper R

Publication type: Article

Publication status: Published

Journal: Bone

Year: 2017

Volume: 105

Pages: 115-121

Print publication date: 01/12/2017

Online publication date: 24/08/2017

Acceptance date: 19/08/2017

Date deposited: 20/01/2022

ISSN (print): 8756-3282

ISSN (electronic): 1873-2763

Publisher: Elsevier Inc.


DOI: 10.1016/j.bone.2017.08.017

PubMed id: 28842363


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Funder referenceFunder name
funded by the UK Medical Research Council (Grant MR/L010399/1) which supported SGM, AVP and FRS.
SGM, RC, RJH and DK are supported by the UK Medical Research Council (Programme codes: MC_UU_12019/1, MC_UU_12019/2 and MC_UU_12019/4).
The NSHD is funded by the UK Medical Research Council.