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Lookup NU author(s): Professor Rachel CooperORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2017 Article author(s).Objectives We conducted an individual participant meta-analysis to test the hypothesis that cortisol patterns indicative of dysregulated hypothalamic-pituitary-adrenal axis functioning would be prospectively associated with poorer well-being at follow-up. Setting Four large UK-based cohort studies. Participants Those providing valid salivary or serum cortisol samples (n=7515 for morning cortisol; n=1612 for cortisol awakening response) at baseline (age 44-82) and well-being data on the Warwick Edinburgh Mental Wellbeing Scale at follow-up (0-8 years) were included. Results Well-being was not associated with morning cortisol, diurnal slope or awakening response though a borderline association with evening cortisol was found. Adjusting for sex and follow-up time, each 1 SD increase in evening cortisol was associated with a â'0.47 (95% CI â'1.00 to 0.05) point lower well-being. This was attenuated by adjustment for body mass index, smoking and socioeconomic position. Between-study heterogeneity was low. Conclusions This study does not support the hypothesis that diurnal cortisol is prospectively associated with well-being up to 8 years later. However, replication in prospective studies with cortisol samples over multiple days is required.
Author(s): Stafford M, Ben-Shlomo Y, Cooper C, Gale C, Gardner MP, Geoffroy M-C, Power C, Kuh D, Cooper R
Publication type: Article
Publication status: Published
Journal: BMJ Open
Print publication date: 12/10/2017
Online publication date: 12/10/2017
Acceptance date: 13/07/2017
Date deposited: 20/01/2022
ISSN (electronic): 2044-6055
Publisher: BMJ Publishing Group
PubMed id: 29025828
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