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Chronic physical illness in early life and risk of chronic widespread and regional pain at age 68: Evidence from the 1946 British birth cohort

Lookup NU author(s): Professor Rachel CooperORCiD



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


© 2016 International Association for the Study of Pain.This study aimed to examine the associations between serious illness in earlier life and risk of pain in old age using data from a large nationally representative British birth cohort, the Medical Research Council (MRC) National Survey of Health and Development (NSHD). Serious illness was defined as any experience of illness before age 25 requiring hospital admission of ≥28 days. Pain was self-reported at age 68, with chronic widespread pain (CWP) defined according to American College of Rheumatology criteria. Multinomial logistic regression was used to test associations of serious illness in early life with CWP, chronic regional pain (CRP), and other pain, with no pain as the referent category. Adjustment was made for sex, socioeconomic position, adult health status, health behaviours, and psychosocial factors. Of 2401 NSHD participants with complete data, 10.5% reported CWP (13.2% of women and 7.7% of men), 30.2% reported CRP, and 14.8% other pain. Compared with those with no history of serious illness, those who experienced serious illness in early life had a higher likelihood of CWP (relative risk ratio [RRR] 1.62 [95% CI: 1.21-2.17]) and of CRP (RRR 1.25 [95% CI: 1.01-1.54]) after adjusting for sex. In fully adjusted models, serious illness in early life remained associated with CWP (RRR 1.43 [95% CI: 1.05-1.95]), but associations with CRP were attenuated (RRR 1.19 [95% CI: 0.96-1.48]). There were no associations with other pain. These findings suggest that those who have experienced serious illness in earlier life may require more support than others to minimise their risk of CWP in later life.

Publication metadata

Author(s): Muthuri SG, Kuh D, Bendayan R, Macfarlane GJ, Cooper R

Publication type: Article

Publication status: Published

Journal: Pain

Year: 2016

Volume: 157

Issue: 10

Pages: 2382-2389

Print publication date: 01/10/2016

Online publication date: 14/07/2016

Acceptance date: 05/07/2016

Date deposited: 21/01/2022

ISSN (print): 0304-3959

ISSN (electronic): 1872-6623

Publisher: Lippincott Williams and Wilkins


DOI: 10.1097/j.pain.0000000000000663

PubMed id: 27547897


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