Toggle Main Menu Toggle Search

Open Access padlockePrints

Physical activity across adulthood in relation to fat and lean body mass in early old age: Findings from the Medical Research Council National Survey of Health and Development, 1946-2010

Lookup NU author(s): Professor Rachel CooperORCiD



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Fat and lean body mass have important implications for health and physical functioning in older age, and physical activity is purported to be an important modifiable determinant. However, our evidence-based understanding of its role is limited. We examined the associations of physical activity, assessed both by self-report (using data on leisure time physical activity (LTPA) collected on 4 occasions over a 28-year period) and objectively (using 5-day heart rate and movement monitoring), with fat and lean mass at ages 60-64 years in 1,162 British participants from the Medical Research Council National Survey of Health and Development in 1946-2010. Higher objectively assessed physical activity energy expenditure (PAEE) at ages 60-64 years was associated with lower fat mass and android (abdominal):gynoid (hip) fat ratio (mean differences in fat mass per 1-standard deviation increase in PAEE were -0.79 kg/m1.2 in men (95% confidence interval: -1.08, -0.50) and -1.79 kg/m1.2 (95% confidence interval: -2.15, -1.42) in women). After adjustment for fat mass, higher PAEE was associated with higher appendicular lean mass. Both light and moderate-to-vigorous intensities of activity were associated with fat mass, and the latter was associated with lean mass. More frequent LTPA across adulthood was associated with lower fat mass (in women only) and higher appendicular lean mass (in both sexes, after adjustment for fat mass). These results support the promotion of LTPA across adulthood, as well as both light and moderate-to-vigorous intensities of activity among older adults. © 2014 The Author 2014. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health.

Publication metadata

Author(s): Bann D, Kuh D, Wills AK, Adams J, Brage S, Cooper R

Publication type: Article

Publication status: Published

Journal: American Journal of Epidemiology

Year: 2014

Volume: 179

Issue: 10

Pages: 1197-1207

Print publication date: 15/05/2014

Online publication date: 09/04/2014

Acceptance date: 06/02/2014

Date deposited: 17/01/2022

ISSN (print): 0002-9262

ISSN (electronic): 1476-6256

Publisher: Oxford University Press


DOI: 10.1093/aje/kwu033

PubMed id: 24722997


Altmetrics provided by Altmetric


Funder referenceFunder name