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Lookup NU author(s): Dr Ethan SenORCiD
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© 2021, Indian Academy of Pediatrics.Macrophage activation syndrome is a severe yet under-recognized complication encountered in pediatric rheumatology. It manifests as secondary hemophagocytic lymphohistiocytosis leading to a hyper-inflammatory state resulting from an underlying cytokine storm. If unchecked, it may lead to multiorgan failure and mortality. Early diagnosis and timely initiation of specific therapy is pivotal for a successful outcome. This review outlines the key clinical and laboratory features and management of macrophage activation syndrome.
Author(s): Bagri NK, Gupta L, Sen ES, Ramanan AV
Publication type: Review
Publication status: Published
Journal: Indian Pediatrics
Year: 2021
Volume: 58
Issue: 12
Pages: 1155-1161
Print publication date: 01/12/2021
Online publication date: 26/03/2021
Acceptance date: 02/04/2018
ISSN (print): 0019-6061
ISSN (electronic): 0974-7559
Publisher: Springer
URL: https://doi.org/10.1007/s13312-021-2399-8
DOI: 10.1007/s13312-021-2399-8
PubMed id: 33772536