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Macrophage Activation Syndrome in Children: Diagnosis and Management

Lookup NU author(s): Dr Ethan SenORCiD

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Abstract

© 2021, Indian Academy of Pediatrics.Macrophage activation syndrome is a severe yet under-recognized complication encountered in pediatric rheumatology. It manifests as secondary hemophagocytic lymphohistiocytosis leading to a hyper-inflammatory state resulting from an underlying cytokine storm. If unchecked, it may lead to multiorgan failure and mortality. Early diagnosis and timely initiation of specific therapy is pivotal for a successful outcome. This review outlines the key clinical and laboratory features and management of macrophage activation syndrome.

Publication metadata

Author(s): Bagri NK, Gupta L, Sen ES, Ramanan AV

Publication type: Review

Publication status: Published

Journal: Indian Pediatrics

Year: 2021

Volume: 58

Issue: 12

Pages: 1155-1161

Print publication date: 01/12/2021

Online publication date: 26/03/2021

Acceptance date: 02/04/2018

ISSN (print): 0019-6061

ISSN (electronic): 0974-7559

Publisher: Springer

URL: https://doi.org/10.1007/s13312-021-2399-8

DOI: 10.1007/s13312-021-2399-8

PubMed id: 33772536

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