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Lookup NU author(s): Dr Declan Murphy
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© 2021, Crown. Purpose: Albinism defines a group of genetic diseases which result from disordered melanin biosynthesis. Proliferative diabetic retinopathy (PDR) results from poorly controlled type 1 or 2 diabetes mellitus (DM) and can lead to blindness due to progressive neovascularisation. However, the treatment of PDR in patients with ocular/oculocutaneous albinism may be more challenging. In this study, we compared a group of patients with albinism and PDR, to a group with albinism and diabetes mellitus but no PDR, to examine the long-term implications. Methods: Retrospective observational study included all patients with ocular albinism (OA) or oculocutaneous albinism (OCA) and DM who presented at a single specialist centre. Participants were allocated into either group 1 (eyes with PDR) or group 2 (all eyes without PDR). Statistical analysis was performed using SPSS V26.0. Between-group differences were investigated. Results: Outcome data was available for 5 eyes from 3 participants in group 1 and 26 eyes from 13 participants in group 2. Despite interventions, a large and significant difference in vision at follow-up was observed between group 1 and group 2 (mean change in visual acuity: 1.11 (± 1.00) versus − 0.15 (± 0.46), respectively; p = < 0.0001). Conclusion: PDR is associated with poor long-term prognosis despite interventions for patients with albinism. Those without PDR appear to maintain stable vision. Alternative treatments for PDR and its complications may be required in this population. Measures to prevent the development of diabetic eye disease and progression towards PDR should be employed at an early stage. [Figure not available: see fulltext.]
Author(s): Murphy DC, Katta M, Egan CA, Michaelides M, Wickham L
Publication type: Article
Publication status: Published
Journal: Graefe's Archive for Clinical and Experimental Ophthalmology
Year: 2022
Volume: 260
Pages: 2165-2173
Print publication date: 01/07/2022
Online publication date: 24/01/2022
Acceptance date: 01/07/2021
ISSN (print): 0721-832X
ISSN (electronic): 1435-702X
Publisher: Springer Science and Business Media Deutschland GmbH
URL: https://doi.org/10.1007/s00417-021-05313-x
DOI: 10.1007/s00417-021-05313-x
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