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Lookup NU author(s): Dr Chang Lee, Matthew Kennedy
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© 2022 International Association of Oral and Maxillofacial SurgeonsIn locally advanced oral squamous cell carcinoma (OSCC), namely that showing invasion of the mandible, demonstrating no high-risk (e.g. extranodal extension, positive margin) or intermediate-risk histopathological features (e.g. perineural invasion, lymphovascular invasion), the additional benefit of postoperative radiotherapy (PORT) currently remains uncertain. A retrospective review covering the period between January 1, 2010 and December 31, 2019 was conducted to identify patients from a single UK centre with locally advanced invasive mandibular OSCC defined as pT4a, with no nodal or distant metastasis (N0 M0). The primary outcome was to determine the disease-free survival and overall survival rates in the surgery + PORT group, in comparison to the surgery only group. Twenty-eight eligible patients were identified, with 13 patients in the surgery + PORT group and 15 patients in the surgery only group. A single patient in the surgery + PORT group developed disease recurrence and subsequently died (1/13) (median follow-up 5.24 years, range 2.13–10.71 years). No patient in the surgery only group developed disease recurrence or died (0/15) (median follow-up 5.13 years, range 1.37–10.93 years). It may be reasonable to consider omitting PORT in pT4a pN0 M0 OSCC of the mandible in patients who demonstrate no high- or intermediate-risk histopathological features, following multidisciplinary team discussion.
Author(s): Lee CW, Jenkins GW, Lee-Warder L, Kennedy M, Iqbal MS, Adams J
Publication type: Article
Publication status: Published
Journal: International Journal of Oral and Maxillofacial Surgery
Year: 2022
Volume: 51
Issue: 10
Pages: 1251-1256
Print publication date: 01/10/2022
Online publication date: 25/01/2022
Acceptance date: 10/01/2022
ISSN (print): 0901-5027
ISSN (electronic): 1399-0020
Publisher: Churchill Livingstone
URL: https://doi.org/10.1016/j.ijom.2022.01.003
DOI: 10.1016/j.ijom.2022.01.003
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