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Quantifying test-retest reliability of repeated objective attentional measures in Lewy body dementia

Lookup NU author(s): Dr Greg Elder, Dr Sean Colloby, Dr Michael FirbankORCiD, Professor John-Paul TaylorORCiD

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Abstract

© 2022, The Author(s).Objective cognitive impairment is a feature of Lewy body dementia (LBD), and computerised attentional tasks are commonly used as outcome measures in interventional trials. However, the reliability of these measures, in the absence of interventions, are unknown. This study examined the reliability of these attentional measures at short-term and longer-term follow-up stages. LBD patients (n = 36) completed computerised attentional tasks [simple and choice reaction time, and digit vigilance (SRT, CRT, DV)] at short-term (Day 0–Day 5) and longer-term (4 and 12 weeks) follow-up. Intra-class correlations (ICCs) were calculated to assess test–retest reliability. At short-term, the reciprocal SRT, CRT and DV mean reaction time to correct answers, the reciprocal DV coefficient of variation, and reciprocal power of attention (PoA) all showed excellent levels of reliability (all ICCs > 0.90). The reciprocal PoA showed the highest level of reliability (ICC = 0.978). At longer-term follow-up, only the reciprocal PoA had excellent levels of reliability (ICC = 0.927). Reciprocal SRT, CRT and DV reaction time to correct answers, and the CRT coefficient of variation values, showed good levels of test–retest reliability (ICCs ≥ 0.85). Contrary to expectations, most attentional measures demonstrated high levels of test–retest reliability at both short-term and longer-term follow-up time points. The reciprocal PoA composite measure demonstrated excellent levels of test–retest reliability, both in the short-term and long-term. This indicates that objective attentional tasks are suitable outcome measures in LBD studies and that the composite PoA measure may offer the highest levels of reliability.


Publication metadata

Author(s): Elder GJ, Colloby SJ, Firbank MJ, Taylor J-P

Publication type: Article

Publication status: Published

Journal: Journal of Neurology

Year: 2022

Pages: Epub ahead of print

Online publication date: 27/01/2022

Acceptance date: 18/01/2022

Date deposited: 10/03/2022

ISSN (print): 0340-5354

ISSN (electronic): 1432-1459

Publisher: Springer Nature

URL: https://doi.org/10.1007/s00415-022-10977-4

DOI: 10.1007/s00415-022-10977-4

PubMed id: 35084558


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