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Fluctuations in EEG band power at subject-specific timescales over minutes to days explain changes in seizure evolutions

Lookup NU author(s): Mariella Panagiotopoulou, Christoforos Papasavvas, Dr Gabrielle SchroederORCiD, Dr Rhys ThomasORCiD, Dr Peter TaylorORCiD



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


© 2022 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. Epilepsy is recognised as a dynamic disease, where both seizure susceptibility and seizure characteristics themselves change over time. Specifically, we recently quantified the variable electrographic spatio-temporal seizure evolutions that exist within individual patients. This variability appears to follow subject-specific circadian, or longer, timescale modulations. It is therefore important to know whether continuously recorded interictaliEEG features can capture signatures of these modulations over different timescales. In this study, we analyse continuous intracranial electroencephalographic (iEEG) recordings from video-telemetry units and find fluctuations in iEEG band power over timescales ranging from minutes up to 12 days. As expected and in agreement with previous studies, we find that all subjects show a circadian fluctuation in their iEEG band power. We additionally detect other fluctuations of similar magnitude on subject-specific timescales. Importantly, we find that a combination of these fluctuations on different timescales can explain changes in seizure evolutions in most subjects above chance level. These results suggest that subject-specific fluctuations in iEEG band power over timescales of minutes to days may serve as markers of seizure modulating processes. We hope that future study can link these detected fluctuations to their biological driver(s). There is a critical need to better understand seizure modulating processes, as this will enable the development of novel treatment strategies that could minimise the seizure spread, duration or severity and therefore the clinical impact of seizures.

Publication metadata

Author(s): Panagiotopoulou M, Papasavvas CA, Schroeder GM, Thomas RH, Taylor PN, Wang Y

Publication type: Article

Publication status: Published

Journal: Human Brain Mapping

Year: 2022

Volume: 43

Issue: 8

Pages: 2460-2477

Print publication date: 01/06/2022

Online publication date: 04/02/2022

Acceptance date: 23/01/2022

Date deposited: 07/03/2022

ISSN (print): 1065-9471

ISSN (electronic): 1097-0193

Publisher: John Wiley and Sons Inc.

URL: .

DOI: 10.1002/hbm.25796

PubMed id: 35119173


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Funder referenceFunder name
208940/Z/17/ZWellcome Trust