Browse by author
Lookup NU author(s): Dr Anando SenORCiD
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Knowledge reuse of cancer trial designs may benefit from a temporal understanding of the evolution of the target populations of cancer studies over time. Therefore, we conducted a retrospective analysis of the trends of cancer trial eligibility criteria between 1999 and 2014. The yearly distributions of eligibility concepts for chemicals and drugs, procedures, observations, and medical conditions extracted from free-text eligibility criteria of 32,000 clinical trials for 89 cancer types were analyzed. We identified the concepts that trend upwards or downwards in all or selected cancer types, and the concepts that show anomalous trends for some cancers. Later, concept trends were studied in a disease-specific manner and illustrated for breast cancer. Criteria trends observed in this study are also validated and interpreted using evidence from the existing medical literature. This study contributes a method for concept trend analysis and original knowledge of the trends in cancer clinical trial eligibility criteria.
Author(s): Yaman A, Chakrabarti S, Sen A, Weng C
Publication type: Conference Proceedings (inc. Abstract)
Publication status: Published
Conference Name: AMIA Joint Summits on Translational Science
Year of Conference: 2016
Online publication date: 20/07/2016
Acceptance date: 02/11/2015
Publisher: American Medical Informatics Association
PubMed id: 27570681