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Internal Dosimetry in Nuclear Medicine Using GATE and XCAT Phantom: A Simulation Study

Lookup NU author(s): Dr Anando SenORCiD


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PurposeMonte Carlo simulations are routinely used for internal dosimetry studies. These studies are conducted with humanoid phantoms such as the XCAT phantom. In this abstract we present the absorbed doses for various pairs of source and target organs using three common radiotracers in nuclear medicine.MethodsThe GATE software package is used for the Monte Carlo simulations. A typical female XCAT phantom is used as the input. Three radiotracers 153Sm, 131I and 99mTc are studied. The Specific Absorbed Fraction (SAF) for gamma rays (99mTc, 153Sm and 131I) and Specific Fraction (SF) for beta particles (153Sm and 131I) are calculated for all 100 pairs of source target organs including brain, liver, lung, pancreas, kidney, adrenal, spleen, rib bone, bladder and ovaries.ResultsThe source organs themselves gain the highest absorbed dose as compared to other organs. The dose is found to be inversely proportional to distance from the source organ. In SAF results of 153Sm, when the source organ is lung, the rib bone, gain 0.0730 (Kg-1) that is more than lung itself.ConclusionThe absorbed dose for various organs was studied in terms of SAF and SF. Such studies hold importance for future therapeutic procedures and optimization of induced radiotracer.

Publication metadata

Author(s): Fallahpoor M, Abbasi M, Sen A, Parach AA, Kalantari F

Publication type: Conference Proceedings (inc. Abstract)

Publication status: Published

Conference Name: Fifty-seventh annual meeting of the American Association of Physicists in Medicine 2015

Year of Conference: 2015

Pages: 3451-3451

Print publication date: 01/06/2015

Online publication date: 29/06/2015

Acceptance date: 15/05/2015

ISSN: 0094-2405

Publisher: Wiley-Blackwell Publishing, Inc.


DOI: 10.1118/1.4924869

Notes: SU-E-T-507

Series Title: Medical Physics