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Persufflation - Current State of Play

Lookup NU author(s): Aaron Buhagiar, Dr Leo Freitas, Dr Bill ScottORCiD



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


With the ever-increasing disparity between the number of patients waiting for organ transplants and the number organs available, some patients are unable to receive life-saving transplantation in time. The present, widely-used form of preservation is proving to be incapable of maintaining organ quality during long periods of preservation and meeting the needs of an ever-changing legislative and transplantation landscape. This has led to the need for improved preservation techniques. One such technique that has been extensively researched is gaseous oxygen perfusion or Persufflation (PSF). This method discovered in the early 20th century has shown promise in providing both longer term preservation and organ reconditioning capabilities for multiple organs including the liver, kidneys, and pancreas. PSF utilises the organs own vascular network to provide oxygen to the organ tissue and maintain metabolism during preservation to avoid hypoxic damage. This review delves into the history of this technique, its multiple different approaches and uses, as well as in-depth discussion of work published in the past 15 years. Finally, we discuss exciting commercial developments which may help unlock the potential for this technique to be applied at scale.

Publication metadata

Author(s): Buhagiar A, Freitas L, Scott III WE

Publication type: Article

Publication status: Published

Journal: Transplantology

Year: 2021

Volume: 2

Issue: 3

Pages: 362-378

Print publication date: 01/09/2021

Online publication date: 17/09/2021

Acceptance date: 06/09/2021

Date deposited: 04/04/2022

ISSN (electronic): 2673-3943

Publisher: MDPI AG


DOI: 10.3390/transplantology2030035


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