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Lookup NU author(s): Professor Heather Cordell, Dr Carmen Martin-RuizORCiD, Dr Louise Robinson, Emeritus Professor Thomas Kirkwood, Fotios Drenos
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© The Author(s) 2021. Published by Oxford University Press on behalf of The Gerontological Society of America. The demographics of Western populations are changing, with an increase in the proportion of older adults. There is evidence to suggest that genetic factors may influence the aging process: studying these may lead to interventions to help individuals live a longer and healthier life. Evidence from several groups indicates that Klotho (KL), a gene encoding a single-pass transmembrane protein that acts as an FGF23 co-receptor, may be associated with longevity and healthy aging. We aimed to explore this area further by comparing the genotype counts in 642 long-lived individuals from the Newcastle 85+ Study with 18 295 middle-aged Newcastle-based controls from the UK Biobank to test whether variants at the KL gene locus are over- or under-represented in older individuals. If KL is associated with longevity, then we would expect the genotype counts to differ between the 2 cohorts. We found that the rs2283368 CC genotype and the rs9536338 C allele, but not the KL-VS haplotype, were associated with reaching very old age. However, these associations did not replicate in the remainder of the UK Biobank cohort. Thus, our results do not reliably support the role of KL as a longevity factor.
Author(s): Amin HA, Cordell HJ, Martin-Ruiz C, Robinson L, Kirkwood T, Blakemore AI, Drenos F
Publication type: Article
Publication status: Published
Journal: The Journals of Gerontology Series A
Year: 2022
Volume: 77
Issue: 3
Pages: 457-461
Online publication date: 05/12/2021
Acceptance date: 28/10/2021
Date deposited: 06/04/2022
ISSN (print): 1079-5006
ISSN (electronic): 1758-535X
Publisher: Oxford University Press
URL: https://doi.org/10.1093/gerona/glab361
DOI: 10.1093/gerona/glab361
PubMed id: 34893828
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