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Lookup NU author(s): Professor Muzlifah Haniffa
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2022. The Author(s). Cutaneous T cell lymphoma (CTCL) represents a heterogeneous group of non-Hodgkin lymphoma distinguished by the presence of clonal malignant T cells. The heterogeneity of malignant T cells and the complex tumor microenvironment remain poorly characterized. With single-cell RNA analysis and bulk whole-exome sequencing on 19 skin lesions from 15 CTCL patients, we decipher the intra-tumor and inter-lesion diversity of CTCL patients and propose a multi-step tumor evolution model. We further establish a subtyping scheme based on the molecular features of malignant T cells and their pro-tumorigenic microenvironments: the TCyEM group, demonstrating a cytotoxic effector memory T cell phenotype, shows more M2 macrophages infiltration, while the TCM group, featured by a central memory T cell phenotype and adverse patient outcome, is infiltrated by highly exhausted CD8+ reactive T cells, B cells and Tregs with suppressive activities. Our results establish a solid basis for understanding the nature of CTCL and pave the way for future precision medicine for CTCL patients.
Author(s): Liu X, Jin S, Hu S, Li R, Pan H, Liu Y, Lai P, Xu D, Sun J, Liu Z, Gao Y, Zhao Y, Liu F, Xiao Y, Li Y, Wen Y, Chen Z, Xu B, Lin Y, Ran M, Li Q, Yang S, Li H, Tu P, Haniffa M, Teichmann SA, Bai F, Wang Y
Publication type: Article
Publication status: Published
Journal: Nature communications
Year: 2022
Volume: 13
Issue: 1
Online publication date: 03/03/2022
Acceptance date: 14/02/2022
Date deposited: 06/04/2022
ISSN (electronic): 2041-1723
Publisher: Nature Publishing Group
URL: https://doi.org/10.1038/s41467-022-28799-3
DOI: 10.1038/s41467-022-28799-3
PubMed id: 35241665
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