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Lookup NU author(s): Maahendar Porika,
Dr Gabi Saretzki
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Due to their close connection with senescence, aging, and disease, telomeres and telomerase provide a unique and vital research route for boosting longevity and health span. Despite significant advances during the last three decades, earlier studies into these two biological players were impeded by the difficulty of achieving real‐time changes inside living cells. As a result of the clustered regularly interspaced short palindromic repeats (CRISPR)‐associated system’s (Cas) method, targeted genetic studies are now underway to change telomerase, the genes that govern it as well as telomeres. This review will discuss studies that have utilized CRISPR‐related technologies to target and modify genes relevant to telomeres and telomerase as well as to develop targeted anti‐cancer therapies. These studies greatly improve our knowledge and understanding of cellular and molecular mechanisms that underlie cancer development and aging.
Author(s): Porika M, Tippani R, Saretzki GC
Publication type: Review
Publication status: Published
Journal: International Journal of Molecular Sciences
Online publication date: 10/03/2022
Acceptance date: 08/03/2022
ISSN (print): 1661-6596
ISSN (electronic): 1422-0067