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Porocarcinoma: a review

Lookup NU author(s): Professor Neil RajanORCiD


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© 2022 British Association of Dermatologists. From the first report in 1969 to the present day, diagnosis of eccrine porocarcinoma, also known simply as porocarcinoma (PC), remains a challenge. This review presents a concise update of the history, pathogenesis, epidemiology, diagnosis, management and prognosis of this rare sweat gland neoplasm. PC differentiates towards the intraepidermal spiral ducts in the eccrine gland, is more common in people aged > 60 years and often affects the head, neck and legs. PC presents as a dome-shaped papule, plaque or nodule growing over weeks to months. The exact incidence of PC is unknown but appears to be rising. Diagnosis is difficult because of variable presentations and similar clinical and histological features to cutaneous squamous cell carcinoma. Management involves removal of the tumour, usually using wide local excision or Mohs micrographic surgery. Prognosis is poor, with PC recurring after surgery in 35% of cases. Given the lack of standardized protocols and risk profiles, further studies would help improve the understanding of PC.

Publication metadata

Author(s): Joshy J, Mistry K, Levell NJ, van Bodegraven B, Vernon S, Rajan N, Craig P, Venables ZC

Publication type: Review

Publication status: Published

Journal: Clinical and Experimental Dermatology

Year: 2022

Volume: 47

Issue: 6

Pages: 1030-1035

Online publication date: 11/02/2022

Acceptance date: 07/02/2022

ISSN (print): 0307-6938

ISSN (electronic): 1365-2230

Publisher: John Wiley and Sons Inc


DOI: 10.1111/ced.15126

PubMed id: 35149987