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Lookup NU author(s): Professor Neil RajanORCiD
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© 2022 British Association of Dermatologists. From the first report in 1969 to the present day, diagnosis of eccrine porocarcinoma, also known simply as porocarcinoma (PC), remains a challenge. This review presents a concise update of the history, pathogenesis, epidemiology, diagnosis, management and prognosis of this rare sweat gland neoplasm. PC differentiates towards the intraepidermal spiral ducts in the eccrine gland, is more common in people aged > 60 years and often affects the head, neck and legs. PC presents as a dome-shaped papule, plaque or nodule growing over weeks to months. The exact incidence of PC is unknown but appears to be rising. Diagnosis is difficult because of variable presentations and similar clinical and histological features to cutaneous squamous cell carcinoma. Management involves removal of the tumour, usually using wide local excision or Mohs micrographic surgery. Prognosis is poor, with PC recurring after surgery in 35% of cases. Given the lack of standardized protocols and risk profiles, further studies would help improve the understanding of PC.
Author(s): Joshy J, Mistry K, Levell NJ, van Bodegraven B, Vernon S, Rajan N, Craig P, Venables ZC
Publication type: Review
Publication status: Published
Journal: Clinical and Experimental Dermatology
Year: 2022
Volume: 47
Issue: 6
Pages: 1030-1035
Online publication date: 11/02/2022
Acceptance date: 07/02/2022
ISSN (print): 0307-6938
ISSN (electronic): 1365-2230
Publisher: John Wiley and Sons Inc
URL: https://doi.org/10.1111/ced.15126
DOI: 10.1111/ced.15126
PubMed id: 35149987
