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Development of the Human Arterial Valves: Understanding Bicuspid Aortic Valve

Lookup NU author(s): Professor Deborah HendersonORCiD, Dr Lorraine Eley, Jasmin TurnerORCiD, Dr Bill Chaudhry


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Abnormalities in the arterial valves are some of the commonest congenital malformations, with bicuspid aortic valve (BAV) occurring in as many as 2% of the population. Despite this, most of what we understand about the development of the arterial (semilunar; aortic and pulmonary) valves is extrapolated from investigations of the atrioventricular valves in animal models, with surprisingly little specifically known about how the arterial valves develop in mouse, and even less in human. In this review, we summarise what is known about the development of the human arterial valve leaflets, comparing this to the mouse where appropriate

Publication metadata

Author(s): Henderson DJ, Eley L, Turner JE, Chaudhry B

Publication type: Review

Publication status: Published

Journal: Frontiers in Cardiovascular Medicine

Year: 2022

Volume: 8

Print publication date: 27/01/2022

Online publication date: 27/01/2022

Acceptance date: 16/12/2021

ISSN (electronic): 2297-055X


DOI: 10.3389/fcvm.2021.802930

PubMed id: 35155611