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Glycan processing in gut microbiomes

Lookup NU author(s): Lauren McKee, Dr Elisabeth Lowe



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


© 2022 The Author(s). Microbiomes and their enzymes process many of the nutrients accessible in the gastrointestinal tract of bilaterians and play an essential role in host health and nutrition. In this review, we describe recent insights into nutrient processing in microbiomes across three exemplary yet contrasting gastrointestinal ecosystems (humans, ruminants and insects), with focus on bacterial mechanisms for the utilization of common and atypical dietary glycans as well as host-derived mucus glycans. In parallel, we discuss findings from multi-omic studies that have provided new perspectives on understanding glycan-dependent interactions and the complex food-webs of microbial populations in their natural habitat. Using key examples, we emphasize how increasing understanding of glycan processing by gut microbiomes can provide critical insights to assist ‘microbiome reprogramming’, a growing field that seeks to leverage diet to improve animal growth and host health.

Publication metadata

Author(s): La Rosa SL, Ostrowski MP, Vera-Ponce de Leon A, McKee LS, Larsbrink J, Eijsink VG, Lowe EC, Martens EC, Pope PB

Publication type: Review

Publication status: Published

Journal: Current Opinion in Microbiology

Year: 2022

Volume: 67

Print publication date: 01/06/2022

Online publication date: 23/03/2022

Acceptance date: 02/04/2018

ISSN (print): 1369-5274

ISSN (electronic): 1879-0364

Publisher: Elsevier Ltd


DOI: 10.1016/j.mib.2022.102143