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Oral health status after hematopoietic stem cell transplantations: Outcomes from an adult Italian population

Lookup NU author(s): Professor Marco Carrozzo


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© 2022 Special Care Dentistry Association and Wiley Periodicals LLC. Aim: To describe oral cavity changes in patients who underwent a hematopoietic stem cell transplantation (HSCT). Methods and results: A group of 32 patients was studied after a mean period of 48.8 months (±11.22) from HSCT; oral, dental, and periodontal status were collected and compared with those of healthy matched controls. Unstimulated whole salivary flow (UWS) and salivary pH were also measured. A validated questionnaire (EORTC QLQH&N-35) was used for reported quality of life. Fifty-nine percent of patients were affected by chronic graft-versus-host disease (cGVHD). Dental health and periodontal status were statistically worse than in controls (P =.003 and P =.008, respectively). Regarding the HSCT group, UWS was statistically lower, and EORTC QLQH&N-35 significantly higher than those reported in controls (P =.000 for both). There was no statistical correlation between hypo-salivation and conditioning, presence of cGVHD, type of medication used before and after transplantation, and time of follow-up. A reduction in salivary pH has been noted only for patients with erosive oral lesions. Conclusion: The oral cavity of HSCT patients appeared to undergo substantial modifications and the quality of life was deeply compromised.

Publication metadata

Author(s): Arduino PG, Gambino A, Giaccone L, Suria M, Carbone M, Carrozzo M, Broccoletti R, Conrotto D

Publication type: Article

Publication status: Published

Journal: Special Care in Dentistry

Year: 2022

Volume: 42

Issue: 6

Pages: 585-591

Print publication date: 01/11/2022

Online publication date: 24/03/2022

Acceptance date: 04/03/2022

ISSN (print): 0275-1879

ISSN (electronic): 1754-4505

Publisher: John Wiley and Sons Inc.


DOI: 10.1111/scd.12715


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