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Lookup NU author(s): Professor Moein MoghimiORCiD
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© 2022 Elsevier Ltd. The complement system is a group of soluble and membrane-bound proteins belonging to the innate arm of the immune system, offering protection against intruders, including drug delivery systems, as well as regulating host homeostasis. However, when uncontrolled, complement activation could trigger inflammatory reactions. Considering these, careful assessment of complement activation by particulate medicines becomes important, since over activation of the complement system could negatively impact their therapeutic potential. For careful complement analysis, meticulous handling and characterisation of sera/plasma is needed but regularly omitted by the research community. Here, we draw attention to this problem and call for implementation of quality assessment guidelines in sera/plasma preparation, storage and validation. We further highlight critical and variable biological factors that affect complement evaluation. These measure are necessary for reproducible complement mapping and for eliminating erroneous conclusions on complement evasion/activation properties of investigational and regulatory-approved particulate medicines.
Author(s): Moghimi SM, Simberg D
Publication type: Note
Publication status: Published
Journal: Nano Today
Year: 2022
Volume: 44
Print publication date: 01/06/2022
Online publication date: 07/04/2022
Acceptance date: 29/03/2022
ISSN (print): 1748-0132
ISSN (electronic): 1878-044X
Publisher: Elsevier B.V.
URL: https://doi.org/10.1016/j.nantod.2022.101479
DOI: 10.1016/j.nantod.2022.101479
