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Lookup NU author(s): Dr Kevin WaldronORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Bacteria have evolved mechanisms which enable them to control intracellular concentrations of metals. In the case of transition metals, such as copper, iron and zinc, bacteria must ensure enough is available as a cofactor for enzymes whilst at the same time preventing the accumulation of excess concentrations, which can be toxic. Interestingly, metal homeostasis and resistance systems have been found to play important roles in virulence. This review will discuss the copper homeostasis and resistance systems in Staphylococcus aureus and Listeria monocytogenes and the implications that acquisition of additional copper resistance genes may have in these pathogens.
Author(s): Kaur I, Purves J, Harwood M, Ketley JM, Andrew PW, Waldron KJ, Morrissey JA
Publication type: Article
Publication status: Published
Online publication date: 11/04/2022
Acceptance date: 16/02/2022
Date deposited: 25/04/2022
ISSN (print): 1350-0872
ISSN (electronic): 1465-2080
Publisher: Microbiology Society
PubMed id: 35404222
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