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Role of horizontally transferred copper resistance genes in Staphylococcus aureus and Listeria monocytogenes

Lookup NU author(s): Dr Kevin WaldronORCiD



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Bacteria have evolved mechanisms which enable them to control intracellular concentrations of metals. In the case of transition metals, such as copper, iron and zinc, bacteria must ensure enough is available as a cofactor for enzymes whilst at the same time preventing the accumulation of excess concentrations, which can be toxic. Interestingly, metal homeostasis and resistance systems have been found to play important roles in virulence. This review will discuss the copper homeostasis and resistance systems in Staphylococcus aureus and Listeria monocytogenes and the implications that acquisition of additional copper resistance genes may have in these pathogens.

Publication metadata

Author(s): Kaur I, Purves J, Harwood M, Ketley JM, Andrew PW, Waldron KJ, Morrissey JA

Publication type: Article

Publication status: Published

Journal: Microbiology

Year: 2022

Volume: 168

Issue: 4

Online publication date: 11/04/2022

Acceptance date: 16/02/2022

Date deposited: 25/04/2022

ISSN (print): 1350-0872

ISSN (electronic): 1465-2080

Publisher: Microbiology Society


DOI: 10.1099/mic.0.001162

PubMed id: 35404222


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