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Lookup NU author(s): Dr Matthew WilcoxORCiD, Dr Peter Chater, Kyle Stanforth, Professor Jeffrey Pearson
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).
© 2022 AME Publishing Company. All Rights Reserved. Background: Satiety in the stomach is often caused by distension and the satiating feeling is triggered through afferent vagal signals. Increasing or prolonging the distension of the stomach with a low-calorie agent would be beneficial in reducing the energy intake and potentially aid in the management of weight. The aim of this work was to quantify the rheological properties of an alginate formulation to induce satiety (AFIS) as it passes through a physiologically relevant model of human digestive tract. Methods: A physiologically relevant model of oral, gastric and small intestinal digestion was used to simulate in vivo conditions, including digestive capacity and physical forces. Samples were taken from the model and the rheological properties and viscosity of them assessed. This was repeated in the presence of a mixed meal. Results: The addition of the AFIS gelled strongly in the gastric phase of the model gut system and reformed the gel after shear stress disrupted the gel network. The inclusion of the formulation to induce satiety with a mixed meal to the model gut system increased the viscosity in the gastric phase to a greater extent than just the formulation alone. Conclusions: The forces generated by the stomach in vivo would be sufficient to eventually overcome the gelled formulation and with the repeated breakdown and additional gastric secretions would eventually allow passage into the small intestine. The synergistic increase in viscosity seen with the mixed meal and the formulation indicated an interaction between the formulation and the meal. The AFIS would potentially increase the retention time of gastric contents as well as gelling strongly. However, the forces generated by the stomach in vivo would eventually be sufficient to breakdown the formulation, and with the additional gastric secretion, allow it to pass into the small intestine, avoiding indefinite retention.
Author(s): Wilcox MD, Chater PI, Stanforth KJ, Woodcock AD, Dettmar PW, Pearson JP
Publication type: Article
Publication status: Published
Journal: Annals of Esophagus
Year: 2022
Volume: 5
Online publication date: 25/03/2022
Acceptance date: 08/03/2021
Date deposited: 09/05/2022
ISSN (electronic): 2616-2784
Publisher: AME Publishing Company
URL: https://doi.org/10.21037/AOE-20-89
DOI: 10.21037/AOE-20-89
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