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Lookup NU author(s): Dr Vickyanne Carruthers,
Dr Shelby BarnettORCiD,
Dr Tasnim Arif,
Professor Gareth Veal
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2022 The Authors. Pediatric Blood & Cancer published by Wiley Periodicals LLC. Infantile myofibroma is a rare, benign tumour of infancy typically managed surgically. In a minority of cases, more aggressive disease is seen and chemotherapy with vinblastine and methotrexate may be used, although evidence for this is limited. Chemotherapy dosing in infants is challenging, and vinblastine disposition in infants is unknown. We describe the use of vinblastine therapeutic drug monitoring in four cases of infantile myofibroma. Marked inter- and intrapatient variability was observed, highlighting the poorly understood pharmacokinetics of vinblastine in children, the challenges inherent in treating neonates, and the role of adaptive dosing in optimising drug exposure in challenging situations.
Author(s): Carruthers V, Barnett S, Rees R, Arif T, Slater O, Ramanujachar R, Johnson K, Brown S, Graham C, Burke GAA, Veal GJ
Publication type: Article
Publication status: Published
Journal: Pediatric Blood and Cancer
Print publication date: 01/07/2022
Online publication date: 20/04/2022
Acceptance date: 15/03/2022
Date deposited: 17/05/2022
ISSN (print): 1545-5009
ISSN (electronic): 1545-5017
Publisher: John Wiley and Sons Inc.
PubMed id: 35441483
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