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Reactivity of posterior cortical electroencephalographic alpha rhythms during eyes opening in cognitively intact older adults and patients with dementia due to Alzheimer's and Lewy body diseases

Lookup NU author(s): Dr Dag Aarsland, Professor John-Paul TaylorORCiD, Julia Schumacher, Professor Ian McKeith

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Abstract

© 2022 Elsevier Inc. Please modify the Abstract as follows:Here we tested if the reactivity of posterior resting-state electroencephalographic (rsEEG) alpha rhythms from the eye-closed to the eyes-open condition may differ in patients with dementia due to Lewy Bodies (DLB) and Alzheimer's disease (ADD) as a functional probe of the dominant neural synchronization mechanisms regulating the vigilance in posterior visual systems.We used clinical, demographical, and rsEEG datasets in 28 older adults (Healthy), 42 DLB, and 48 ADD participants. The eLORETA freeware was used to estimate cortical rsEEG sources.Results showed a substantial (> -10%) reduction in the posterior alpha activities during the eyes-open condition in 24 Healthy, 26 ADD, and 22 DLB subjects. There were lower reductions in the posterior alpha activities in the ADD and DLB groups than in the Healthy group. That reduction in the occipital region was lower in the DLB than in the ADD group.These results suggest that DLB patients may suffer from a greater alteration in the neural synchronization mechanisms regulating vigilance in occipital cortical systems compared to ADD patients.

Publication metadata

Author(s): Babiloni C, Lorenzo I, Lizio R, Lopez S, Tucci F, Ferri R, Soricelli A, Nobili F, Arnaldi D, Fama F, Buttinelli C, Giubilei F, Cipollini V, Onofrj M, Stocchi F, Vacca L, Fuhr P, Gschwandtner U, Ransmayr G, Aarsland D, Parnetti L, Marizzoni M, D'Antonio F, De Lena C, Guntekin B, Yildirim E, Hanoglu L, Yener G, Gunduz DH, Taylor JP, Schumacher J, McKeith I, Frisoni GB, De Pandis MF, Bonanni L, Percio CD, Noce G

Publication type: Article

Publication status: Published

Journal: Neurobiology of Aging

Year: 2022

Volume: 115

Pages: 88-108

Print publication date: 01/07/2022

Online publication date: 09/04/2022

Acceptance date: 02/04/2022

ISSN (print): 0197-4580

ISSN (electronic): 1558-1497

Publisher: Elsevier Inc.

URL: https://doi.org/10.1016/j.neurobiolaging.2022.04.001

DOI: 10.1016/j.neurobiolaging.2022.04.001

PubMed id: 35512497

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